Endocrine Abstracts

Introduction: The HECa10 line was derived from the specialized endothelial cells typically occurring in lymphoid tissues and belonging to high endothelial vessels (HEVs). Recent studies have shown that HEVs are also present within the tumor microenvironment, what unlike to other blood vessels, can be associated with favorable prognosis of cancer patients. Estradiol (E2) and its metabolite 2-methoxyestradiol (2ME2) are known as the important modulators of cardiovascular system ...

Apoptosis is an important process influencing tissues growth, however the assessment of this process in monolayer culture is difficult because apoptotic cells disappear quickly due to secondary necrosis. Most of the methods used with success in vivo is useless in vitro. Our approach to evaluating apoptosis in vitro is based on the possibility to perform multiple assays on the same sample well. The aim of the study was to evaluate the effect of mifepristone (RU-486), a...